Turning ‘fate’ into destiny by seizing a second chance at life

Turning 'fate' into destiny by seizing a second chance at life.

Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.

Stem cells are found in various organs where they participate in tissue homeostasis by replacing differentiated cells lost to physiological turnover or injury. An investigation was performed to determine whether stem cells are restricted to produce specific cell types, namely, those from the tissue in which they reside. After transplantation into irradiated hosts, genetically labeled neural ste...

A second chance at success: A political economy perspective

This paper characterizes a stationary Markov-perfect political equilibrium where agents vote over income taxation that distorts educational investment. Agents become rich or poor through educational investment, and the poor have a second chance at success. The results show the following concerning the cost of a second chance. First, when the cost is low, the economy is characterized by high lev...

Turning Waste into By-Product

This paper studies how the conversion of a waste stream into a useful and saleable by-product affects a firm’s optimal operating strategy. We determine whether local implementation can be optimal, i.e., continuing business-as-usual to produce the original product and merely converting the collaterally generated waste stream into by-product, or whether global implementation – that re-optimizes t...

Chance, Destiny, and the Inner Workings of ClpXP

AAA+ proteases are responsible for protein degradation in all branches of life. Using single-molecule and ensemble assays, Cordova et al. investigate how the bacterial protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic model that recapitulates the interplay between stochastic and deterministic behaviors of ClpXP.